dedicated page to research on Toll-like Receptors and HIV-1 Research
Items recommended to this group by its members
- recommended by whitetommi
Science (New York, N.Y.)2008 Apr 18;320(5874):379-81Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR
- TLR3-dsRNA structure paper from Dave Davies Labrecommended by whitetommi
Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a molecular signature of most viruses, and triggers inflammatory responses that prevent viral spread. TLR3 ectodomains (ECDs) dimerize on oligonucleotides of at least 40 to 50 base pairs in length, the minimal length required for signal transduction.
- Josh's characterization of TLR3 binding cooperativelyrecommended by whitetommi
Toll-like receptors (TLRs) initiate immune responses by recognizing pathogen-associated molecules, but the molecular basis for recognition is poorly understood. In particular, it is unclear how receptor-ligand interactions lead to the initiation of downstream signaling.
- TLR3 monomer structurerecommended by whitetommi
Innate immunity is the first line of defense against invading pathogens. Toll-like receptors (TLRs) act as sentinels of the innate immune system, sensing a variety of ligands from lipopolysaccharide to flagellin to dsRNA through their ligand-binding domain that is composed of leucine-rich repeats (LRRs).
- Putative dsRNA binding site prior to structure determinationrecommended by whitetommi
Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. The TLRs recognize pathogens with their N-terminal ectodomains (ECD), but the molecular basis for this recognition is not known.